Entries in Diabetes (11)

Sunday
Dec082013

Does a gluten-free diet protect mice from Type I diabetes?

Image: Madeleine Price BallA study recently published in PLOS ONE provides evidence that type I diabetes is more frequent and occurs earlier in mice on a gluten-containing diet.  

Key terms:
T1D – Type I diabetes
NOD mice - non-obese diabetic mice
microbiota, microbiome – symbiotic microbes, in this case, the ones in our gut

The key statements from the study's conclusions are highlighted:

"Based on this observation and our findings, we could propose that gluten could contribute to the pathogenesis of T1D in the NOD mouse by decreasing Akkermansia, a genus of GIT microbiota that protects against T1D."

"Alternatively, gluten-containing diets may promote 'pathogenic or diabetogenic' bacteria."

"Further experiments are needed to prove these possibilities."

"In conclusion, we have shown that gluten-free diets significantly delay the onset as well as reduce the overall incidence of spontaneous T1D in NOD mice."

"Gut microbiomes from mice fed gluten-free diets was distinct from those of mice fed diabetogenic, gluten-containing diets. Therefore, gluten could contribute to the pathogenesis of T1D by modulating the gut microflora."

Source

Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome

The study was performed by a team of researchers from:

  • Department of Immunology, Mayo Clinic, Rochester, Minnesota,
  • Department of Dermatology, Mayo Clinic, Rochester, Minnesota, 
  • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
  • Institute for Genomic Biology, University of Illinois, Urbana, Illinois, 
  • Department of Animal & Range Sciences, College of Agriculture, Montana State University, Bozeman, Montana
  • Division of Endocrinology, Diabetes, Metabolism, & Nutrition, Mayo Clinic, Rochester, Minnesota
Friday
Nov152013

Amanda’s journey from sick to wonderful

“In December 2009, I was 25 years old and weighed 210 lbs. I was obese for my 5’5″ frame, never felt well, and was popping handfuls of pills every day just to get by. I was taking 2 anti-depressants, anxiolytics, prescription sleeping pills, courses of Prilosec once or twice a month, acid-blocking pills or antacid tablets 1-3 times a day, anti-diarrhea pills several days a week, and I was constantly catching respiratory infections and frequently took courses of antibiotics. 

“… one fateful day somebody posted a link to Mark’s Daily Apple.”

“I was completely blown away. Everything I thought I knew to be true about diet, health, and weight loss was all wrong.” 

Learn more: I Am Strong, Energized, Off All Medications, and Feel Wonderful!

Thursday
Sep052013

Diabetes in China a "catastrophe"

The most comprehensive nationwide survey for diabetes ever conducted in China shows 11.6 percent of adults, or 114 million, has the disease. The finding, published yesterday in the Journal of the American Medical Association, adds 22 million diabetics, or the population of Australia, to a 2007 estimate and means almost one in three diabetes sufferers globally is in China.

Is it the China Diet?

China ‘Catastrophe’ Hits 114 Million as Diabetes Spreads
Bloomberg

Thursday
Dec202012

How healthy is your heart?

People were considered to have optimal heart health if they met the following criteria: They did not have high blood pressure, high cholesterol or diabetes; they were not overweight, underweight or obese; they did not smoke; they did at least 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity a week; and they ate five or more servings of fruits and vegetables a day.

Few Americans Have 'Healthy' Hearts
MyHealthNewsDaily

Monday
Oct292012

MDA Success Story: Impact of Paleo nutrition on Shawn's Type I diabetes

From Mark's Daily Apple comes another great success story:


Around January of this year a friend exposed me to the paleo diet. I checked it out and was intrigued. I started doing extensive reading and research (during which I came across this website) and decided to give it a try. I slowly started purging out the sugars/carbs/processed foods that were poisoning my body (especially cereal which was a staple of my diet at the time), and whaddya know…my blood sugars and overall health improved drastically, and my insulin requirements dropped like a rock!!!


Read more here.

Sunday
Oct072012

Success Story: Child with remission of diabetes on the Paleo diet

On September 10, 2009, I took my six-year-old daughter to the pediatrician for what I thought was a urinary tract infection. She had been very thirsty and going to the bathroom excessively. Little did I know these were the symptoms of hyperglycemia. Her blood glucose was tested at 542 in the doctor’s office, and she spent two days in the hospital. During that time she was diagnosed with type 1 diabetes…

We decided that all of us needed to clean up our diets. Since we worked out in a CrossFit gym, the diet that came to mind was the Paleo Diet.

What happened next was amazing! My daughters insulin needs plummeted. During the next week, we made numenours calls to the endocrinologist to adjust her dosage downward. After two weeks, she was completely off insulin…

A few months later

We now have a solid six months of total remission under our belts.

JoAnne
The Paleo Answer 

 

Related Posts

Monday
Sep242012

Oceana report: Less ocean-based protein for "costal & small island developing nations"

Image: Oceana

"Coastal and small island developing nations are vulnerability hotspots to food security risks from climate change, ocean acidification and both combined. Many of the high-ranking nations based on climate change indicators are located in the tropics and low latitudes."

"Wild caught seafood is often one of the healthiest and most accessible options for protein in coastal and small island nations. Losing this resource may mean more dependence on less healthy processed foods that are imported from abroad. Communities that have recently made a shift from eating traditional seafood items to importing cheap, processed foods have suffered widespread health problems. For example, in Pacific Island nations about 40 percent of the population has been diagnosed with diabetes, cardiovascular diseases or hypertension. Losing seafood accessibility due to changing ocean conditions may further expand these nationwide health crises."

Ocean-Based Food Security Threatened in a High CO2 World

Tuesday
Sep182012

Patient's fatal heart attack turns doctor to Paleo diet

As I drove home I could not get one thing out of my mind.  This gentleman had been to my office to see me just the week before, and I was very encouraging to him about how things were going.  He was in his early 60’s, and suffered from high blood pressure, diabetes, high cholesterol, and obstructive sleep apnea.  The thing is, they were all VERY WELL CONTROLLED! His blood pressure was perfect, his diabetes numbers mirrored that of a non-diabetic patient, and his cholesterol was well below the goals set by multiple cardiovascular studies.  In addition, his cardiologist had convinced him that his meat based diet was the culprit of his seemingly uncontrollable heart disease, and he had adapted a strict vegan diet for well over a year.  In many parts of the country that’s not too hard to believe, but to a Cajun from the land of boudin and pork cracklins, this was quite the feat! So, I asked myself…how could this skinny, well controlled hypertensive, diabetic, vegan Cajun gentleman in his early 60’s have just died from his fourth heart attack?  Something was wrong!

PaleolithicMD

Monday
Sep102012

THE WEIGHT OF THE NATION, Part One: Consequences of Obesity

By Suzanne

According to Donald Lloyd-Jones MD, Chair of Preventive Medicine, Northwestern University Feinberg School of Medicine, ideal cardiovascular health is characterized by meeting each of the following criteria:

  • Optimal levels of total cholesterol
  • Normal blood pressure
  • Not having diabetes
  • Having a lean BMI
  • Not smoking
  • Participating in recommended levels of physical activity
  • Pursuing a healthy diet

How do you measure up?  Surprisingly, less than 1% of the United States population currently meet these criteria. A key reason: overweight and obesity affect 69% of the U.S. population. The initial one hour segment of the WEIGHT OF THE NATION focuses upon the health consequences of overweight and obesity. Together, they are creating a tsunami of chronic disease costing an additional $150 Billion in health care costs.  

See PART I here.

 

Related Post

THE WEIGHT OF THE NATION

Wednesday
Jul112012

Strawberries focus of new research study

According to the Environmental News Network, a new study on the benefits of strawberries will be presented at the Society of Free Radical Research International Biennial Meeting in London this September. David A Gabel of ENN writes:

Besides their fantastic taste, a new study has found that strawberries have other beneficial health effects. Researchers from the University of Warwick Medical School found that strawberries are extremely effective at preventing the development of heart disease and diabetes.

The research team:

... discovered that extracts from strawberries positively activate a protein in our bodies called Nrf2. This protein has shown to increase antioxidant and other protective activities. It also decreases blood lipids and cholesterol, two factors that can lead to cardiovascular disorders.

Wednesday
Aug312011

Paleolithic Nutrition: Diabetes and the Modern Diet

Copyright iStockphotoBy John Michael

Diabetes, especially its Type 2 variant, is spreading around the world. Globally, there are now “more than 350 million people” who suffer from this insidious disease, according to an article in the British newspaper The Guardian. This article goes on to state, “About three million deaths a year are attributed to diabetes and associated conditions.” Here at home, the Centers for Disease Control (CDC) disclose, “25.8 million people in the United States (8.3% of the population) have diabetes,” and, “of these, 7.0 million have undiagnosed diabetes.” They conclude their list of statistics with this sobering appraisal: “If current trends continue, 1 of 3 U.S. adults will have diabetes by 2050.”

While only a small portion of people with diabetes worldwide suffer from Type 1, which is, according to the CDC, “an autoimmune disease that may be caused by genetic, environmental, or other factors,” the majority of suffers worldwide have Type 2 Diabetes, which is “usually associated with older age, obesity and physical inactivity, family history of type 2 diabetes, or a personal history of gestational diabetes.” Both disorders concern either “a shortage of insulin” in the body, “or a decreased ability to use insulin, or both.” Mark’s Daily Apple has a great blog that explains the complex dynamics of this disease here.

In an excellent article on the growing consensus that excess dietary carbohydrates are connected to the growth of modern diseases like heart disease, obesity, hypertension, and type 2 diabetes, The Los Angeles Times quotes several medical experts. 

"Fat is not the problem," says Dr. Walter Willett, chairman of the department of nutrition at the Harvard School of Public Health. "If Americans could eliminate sugary beverages, potatoes, white bread, pasta, white rice and sugary snacks, we would wipe out almost all the problems we have with weight and diabetes and other metabolic diseases."

"Dietary fat used to be public enemy No. 1," says Dr. Edward Saltzman, associate professor of nutrition and medicine at Tufts University. "Now a growing and convincing body of science is pointing the finger at carbs, especially those containing refined flour and sugar." 

"The country's big low-fat message backfired," says Dr. Frank Hu, professor of nutrition and epidemiology at the Harvard School of Public Health. "The overemphasis on reducing fat caused the consumption of carbohydrates and sugar in our diets to soar. That shift may be linked to the biggest health problems in America today."

While a consensus has not yet been achieved among medical professionals as to whether excess carbohydrates and sugar are indeed responsible for the uptick in modern diseases like type 2 diabetes, the message captured in the Los Angeles Times article is echoed by Mark Sisson, who, on his blog, excoriates a reputable diabetes organization’s suggestion that sufferers include in their diets large portions of “breads, grains, beans, pasta, and other starches.” “If you want to develop type 2 diabetes,” he writes regarding the organization’s nutritional advice, “I’m stumped for a more expeditious way to do it.”

By shifting from the typical American to a modern approximation of the Paleolithic diet, we come to eat foods that our bodies are adapted to digesting efficiently. Novel foods like the processed grains that comprise the typical diet's excess in carbohydrates, are quickly converted to blood sugar, which, if not used, as is often the case with calories in our sedentary society, is then stored as fat. As our waistlines burgeon, our risk for type 2 diabetes increases; a Paleo diet, which avoids industrial foods in favor of more ancestral fare, reduces our waistlines, and so, by restoring our natural state of health, protects us from the specter of modern disease.

Related Entries
Paleolithic Nutrition: Diet in the Neolithic  
Paleolithic Nutrition: Diet and Modern Disease